Masoprocol

Actions Thought to have antiproliferative activity against keratinocytes.

 Indications Topical treatment of actinic (solar) keratoses.

 Contraindications Standard considerations.

 Route/Dosage ADULTS: Topical Massage evenly into area containing actinic keratoses each morning and evening for 28 days.

Interactions None well documented.

Lab Test Interferences None well documented.

 Adverse Reactions

DERMATOLOGIC: Erythema; flaking; itching; dryness; edema; burning; soreness; bleeding; crusting; oozing; rash; skin irritation; stinging; tightness; tingling. EENT: Eye irritation.

 Precautions

Pregnancy: Category B. Lactation: Undetermined. Children: Safety and efficacy not established. Application: Occlusive dressings should not be used with this product. External use: This product is for external use only. Avoid contact with eyes and mucous membranes. Sulfite sensitivity: Use caution in sulfite-sensitive individuals; preparation contains bisulfites.

 Administration/Storage

• Before application, wash, rinse, and dry affected area.
• Apply each morning and evening for 28 days. Gently and evenly massage into affected area.
• Wash hands immediately after application.
• Avoid contact with eyes or mucous membranes. If contact occurs, promptly flush eye or mucous membranes with water.
• Do not cover with occlusive dressing.
• Store at room temperature.

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Assess number and severity of lesions before beginning therapy and throughout use of medication.
• Assess area after administration for local reactions such as redness, flaking, itching, dryness, swelling, continued burning, oozing, blistering or bleeding.
• If adverse reactions occur, notify health care provider immediately.

 Patient/Family Education

• Explain proper method of administration. Tell patient that temporary stinging or burning sensation is common but should disappear quickly.
• Warn patient that medication may stain clothing or other fabrics.
• Advise patient not to use makeup or other skin products without consulting health care provider.
• Caution patient to avoid excessive exposure to sun.
• Instruct patient to avoid taking any other medications unless prescribed by health care provider.