Haemophilus b Conjugate Vaccine
Actions
Indications
Contraindications
Route/Dosage
Interactions
Lab Test Interferences
Adverse Reactions
Precautions
Patient Care Considerations
Administration/Storage
Assessment/Interventions
Patient/Family Education
(hem-AHF-ill-us)
ActHIB
Powder for Injection, lyophilized
10 mcg purified capsular polysaccharide, 24 mcg tetanus toxoid/0.5 mL
Comvax
Injection
7.5 mcg Haemophilus b PRP purified capsular polysaccharide, 125 mcg Neisseria meningitidis OMPC, 5 mcg hepatitis B surface antigen, » 225 mcg aluminum, and 35 mcg sodium borate/0.5 mL
HibTITER
Injection
10 mcg purified Haemophilus b saccharide capsular oligosaccharide, » 25 mcg diphtheria CRM197 protein/0.5 mL dose
PedvaxHIB, Liquid
Injection
7.5 mcg Haemophilus b PRP, 125 mcg Neisseria meningitidis OMPC, and 225 mcg aluminum/0.5 mL
Class: Vaccine, inactivated bacteria
Actions Induces specific protective antibodies against Haemophilus influenzae type b (Hib).
Indications Induction of active immunity against Hib infection. Routine immunization of all infants beginning at age 2 mo is recommended.
Contraindications Hypersensitivity to any product component (some products contain thimerosal).
Route/Dosage
HibTITER: Pediatric IM Beginning at 2 mo of age, give 3 doses, 2 mo apart, plus a booster dose at 15 mo. ActHIB: Pediatric IM Beginning at 2 mo of age, give 3 doses, 2 mo apart, plus a booster dose at 15 to 18 mo. PedvaxHIB: Pediatric IM Beginning at 2 mo of age, give 2 doses, 2 mo apart, plus a booster dose at 12 mo.
Interactions None well documented.
Lab Test Interferences Diagnostic value of antigen detection (eg, with latex agglutination kits) may be diminished in suspected Hib disease within few days to 2 wk after immunization.
Adverse Reactions
CNS: Irritability; fever; restless sleep; convulsions. DERMATOLOGIC: Rash; hives. GI: Diarrhea; vomiting; loss of appetite. GU: Renal failure. OTHER: Guillain-Barre syndrome; local erythema; swelling; tenderness; induration.
Precautions
Pregnancy: Category C. Lactation: Undetermined. Children: HibTITER and PedvaxHIB are not recommended in children less than 6 wk of age. Anticoagulant therapy: Administer Hib vaccine with caution to patients receiving anticoagulant therapy. Interchange: In general, complete vaccination series begun with one brand of Hib vaccine with that brand unless specific information about interchangeability is available.
PATIENT CARE CONSIDERATIONS
Administration/Storage
- Administer IM in outer aspect of vastus lateralis, midthigh, or outer aspect of upper arm. Do not inject in gluteal area or near major nerve trunk.
- Do not inject via IV route.
- Inspect product for particulate matter or discoloration. If these conditions exist, do not administer vaccine.
- Keep vaccine refrigerated. Do not freeze.
Assessment/Interventions
- Obtain patient history, including drug history and any known allergies.
- Interview parent or guardian about child's current health. If any febrile illness or active infection is present, vaccine administration may need to be delayed until after recovery. Also question parent or guardian about any allergies the child might have, specifically to any component of vaccine or previous reactions to vaccine.
- Assess for possible anaphylaxis.
Patient/Family Education
- Advise that acetaminophen (appropriate for age) may be given q 4 hr for low-grade fever. Emphasize that aspirin should not be given to children.
- Instruct parent or guardian to report any adverse effects after vaccine administration.
- Remind parent to keep child's immunization record up to date.
Справочник препаратов (англ.) / H
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